Authored by Marina Zhang and Jan Jekielek via The Epoch Times (emphasis ours),
On Jan. 3, the office of Florida Surgeon General Dr. Joseph Ladapo issued a statement calling for the halt in the use of COVID-19 mRNA vaccines, citing the recent discovery of DNA contaminants in the vaccine vials.
On the Jan. 12 episode of EpochTV’s “American Thought Leaders,“ Dr. Ladapo explained why he called for a halt, saying that while there are also safety concerns with the COVID mRNA vaccines linking them to a multitude of adverse events, the recent discovery is ”beyond the pale.”
“DNA is a common contaminant of many biological products,” he told the show’s host, Jan Jekielek. “We can use DNA to produce different drugs like insulin, other biologics—and that’s a wonderful innovation, and normally, that DNA doesn’t pose a problem.”
Human cells are resistant to DNA entry, and this prevents harming the integrity of the cell’s DNA.
However, since the mRNA vaccines use lipid nanoparticles, which deliver mRNA into the cells directly, DNA contaminants could also be able to enter the cells. Some scientists, like Dr. Ladapo, are concerned that the DNA from the vaccine may integrate with the human genome.
Prominent officials at the U.S. Food and Drug Administration (FDA) disagree.
On Dec. 6, Dr. Ladapo sent a letter to FDA commissioner Dr. Robert Califf and the U.S. Centers for Disease Control and Prevention (CDC) director, Dr. Mandy Cohen.
In his letter, he asked if there have been risk assessments of the vaccine DNA integrating into human DNA, especially regarding the controversial SV40 promoter/enhancer region found in Pfizer’s vaccine.
Other questions included whether risk assessments have been done on DNA integration in reproductive cells and if the current levels of DNA residuals are acceptable under the FDA’s standards.
Dr. Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research, replied to Dr. Ladapo on Dec. 14.
“We’ve gotten ... lengthy responses that don’t answer the question,” Dr. Ladapo said.
In his response, Dr. Marks wrote that DNA integration “is quite implausible,” adding that animal studies show “no evidence indicative for genotoxicity.”
No tests were mentioned that would assess if DNA integration is occurring.
Dr. Ladapo believes it would be reckless not to test for DNA integration, a potential risk once DNA enters the cell.
“Their position is, oh, no, it’s fine. Everything’s fine; safe and effective. That’s not only not good enough, but it’s completely unacceptable,” Dr. Ladapo said. “And that’s why I made that determination, and it’s absolutely the correct call.”
DNA Contamination: The SV40 Promoter Controversy
Both Moderna and Pfizer mRNA vaccines contain DNA contaminants, but only the Pfizer vaccines have also been found to contain SV40 promoter/enhancer DNA, which has since become a topic of debate.
SV40, or simian vacuolating virus 40, is a DNA virus that sometimes causes cancer in animals.
However, the SV40 promoter/enhancer found in the vaccines is only a tiny section of the DNA; it is not equivalent to the entire SV40 virus or its protein.
Promoter-enhancers are sections of DNA that can control the activity of other DNA.
“With DNA, there are different regions that tell other parts of DNA whether to be active or not,” Dr. Ladapo said. “This type of control process is very important ... The absence of control can, for example, lead to cancer ... [and] other metabolic abnormalities.”
In his letter to the FDA, Dr. Ladapo asked about the additional risk of the SV40 promoter/enhancer region’s DNA integration.
Dr. Marks answered that there were no genes for SV40 proteins nor SV40 proteins themselves present in the vaccine.
But Dr. Ladapo believes Dr. Marks is intentionally not answering the question.
“No one’s talking about SV40 protein ... we talked about the promoter/enhancer region. They have to be doing it intentionally,” Dr. Ladapo said.
The Risks of DNA Integration
It is currently unknown whether DNA introduced into the body is being integrated into the cell’s human genome; and if it’s integrated, what impact will it have.
Only around 1 percent of the human DNA produces protein; the job of the other 99 percent of DNA is mostly unknown.
“There’s ... a lot of uncertainty about our genome—what it does, how it supports life and creates life, and creates the miracle of each individual human being,” Dr. Ladapo said. “What we do understand is that some of the potential risks of DNA integration include development of cancers, because ... of the regulation of different aspects of DNA and cell growth.
“Other possibilities include the disruption of the normal expression of some proteins, which then subsequently could lead to disruption of normal human function.”
Since biodistribution studies in rats have shown that the mRNA vaccines can accumulate in the reproductive organs, Dr. Ladapo’s letter expressed concern that there may also be DNA integration of reproductive cells.
“We are the most complex beings—the most complex machines, if you will—living machines that exist on this Earth. So I do believe that our genome is part of our connection to God. So that is to say that there’s quite a lot at risk in terms of not taking proper precautions and sensible precautions, with maintaining the integrity to the best that we can—life ain’t perfect, but to the best that we can with our human genome.”
Note: Lapado appeared with Tucker Carlson as well this week
Could foreign DNA enter your cells through the mRNA COVID vax and change your DNA — and humanity itself — forever? Sounds nutty. It's not. "Absolutely that could happen," says Dr. Joseph Ladapo, the surgeon general of Florida. A shocking conversation. pic.twitter.com/Yvt38eStPf
— Tucker Carlson (@TuckerCarlson) January 15, 2024
Authored by Marina Zhang and Jan Jekielek via The Epoch Times (emphasis ours),
On Jan. 3, the office of Florida Surgeon General Dr. Joseph Ladapo issued a statement calling for the halt in the use of COVID-19 mRNA vaccines, citing the recent discovery of DNA contaminants in the vaccine vials.
On the Jan. 12 episode of EpochTV’s “American Thought Leaders,“ Dr. Ladapo explained why he called for a halt, saying that while there are also safety concerns with the COVID mRNA vaccines linking them to a multitude of adverse events, the recent discovery is ”beyond the pale.”
“DNA is a common contaminant of many biological products,” he told the show’s host, Jan Jekielek. “We can use DNA to produce different drugs like insulin, other biologics—and that’s a wonderful innovation, and normally, that DNA doesn’t pose a problem.”
Human cells are resistant to DNA entry, and this prevents harming the integrity of the cell’s DNA.
However, since the mRNA vaccines use lipid nanoparticles, which deliver mRNA into the cells directly, DNA contaminants could also be able to enter the cells. Some scientists, like Dr. Ladapo, are concerned that the DNA from the vaccine may integrate with the human genome.
Prominent officials at the U.S. Food and Drug Administration (FDA) disagree.
On Dec. 6, Dr. Ladapo sent a letter to FDA commissioner Dr. Robert Califf and the U.S. Centers for Disease Control and Prevention (CDC) director, Dr. Mandy Cohen.
In his letter, he asked if there have been risk assessments of the vaccine DNA integrating into human DNA, especially regarding the controversial SV40 promoter/enhancer region found in Pfizer’s vaccine.
Other questions included whether risk assessments have been done on DNA integration in reproductive cells and if the current levels of DNA residuals are acceptable under the FDA’s standards.
Dr. Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research, replied to Dr. Ladapo on Dec. 14.
“We’ve gotten … lengthy responses that don’t answer the question,” Dr. Ladapo said.
In his response, Dr. Marks wrote that DNA integration “is quite implausible,” adding that animal studies show “no evidence indicative for genotoxicity.”
No tests were mentioned that would assess if DNA integration is occurring.
Dr. Ladapo believes it would be reckless not to test for DNA integration, a potential risk once DNA enters the cell.
“Their position is, oh, no, it’s fine. Everything’s fine; safe and effective. That’s not only not good enough, but it’s completely unacceptable,” Dr. Ladapo said. “And that’s why I made that determination, and it’s absolutely the correct call.”
DNA Contamination: The SV40 Promoter Controversy
Both Moderna and Pfizer mRNA vaccines contain DNA contaminants, but only the Pfizer vaccines have also been found to contain SV40 promoter/enhancer DNA, which has since become a topic of debate.
SV40, or simian vacuolating virus 40, is a DNA virus that sometimes causes cancer in animals.
However, the SV40 promoter/enhancer found in the vaccines is only a tiny section of the DNA; it is not equivalent to the entire SV40 virus or its protein.
Promoter-enhancers are sections of DNA that can control the activity of other DNA.
“With DNA, there are different regions that tell other parts of DNA whether to be active or not,” Dr. Ladapo said. “This type of control process is very important … The absence of control can, for example, lead to cancer … [and] other metabolic abnormalities.”
In his letter to the FDA, Dr. Ladapo asked about the additional risk of the SV40 promoter/enhancer region’s DNA integration.
Dr. Marks answered that there were no genes for SV40 proteins nor SV40 proteins themselves present in the vaccine.
But Dr. Ladapo believes Dr. Marks is intentionally not answering the question.
“No one’s talking about SV40 protein … we talked about the promoter/enhancer region. They have to be doing it intentionally,” Dr. Ladapo said.
The Risks of DNA Integration
It is currently unknown whether DNA introduced into the body is being integrated into the cell’s human genome; and if it’s integrated, what impact will it have.
Only around 1 percent of the human DNA produces protein; the job of the other 99 percent of DNA is mostly unknown.
“There’s … a lot of uncertainty about our genome—what it does, how it supports life and creates life, and creates the miracle of each individual human being,” Dr. Ladapo said. “What we do understand is that some of the potential risks of DNA integration include development of cancers, because … of the regulation of different aspects of DNA and cell growth.
“Other possibilities include the disruption of the normal expression of some proteins, which then subsequently could lead to disruption of normal human function.”
Since biodistribution studies in rats have shown that the mRNA vaccines can accumulate in the reproductive organs, Dr. Ladapo’s letter expressed concern that there may also be DNA integration of reproductive cells.
“We are the most complex beings—the most complex machines, if you will—living machines that exist on this Earth. So I do believe that our genome is part of our connection to God. So that is to say that there’s quite a lot at risk in terms of not taking proper precautions and sensible precautions, with maintaining the integrity to the best that we can—life ain’t perfect, but to the best that we can with our human genome.”
Note: Lapado appeared with Tucker Carlson as well this week
Could foreign DNA enter your cells through the mRNA COVID vax and change your DNA — and humanity itself — forever? Sounds nutty. It’s not. “Absolutely that could happen,” says Dr. Joseph Ladapo, the surgeon general of Florida. A shocking conversation. pic.twitter.com/Yvt38eStPf
— Tucker Carlson (@TuckerCarlson) January 15, 2024
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